<p>This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. </p> <p>Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title. </p> <div> <br> </div> <p></p>
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<p>This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. </p> <p>Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology. </p> <div> <br> </div> <p></p>
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By 2100, the human population may exceed 11 billion. Having recently surpassed 7.5 billion, it has trebled since 1950. Are such numbers sustainable, given a deepening environmental crisis? Can so many live well? Or should world population be controlled? The population question, one of the twentieth century's most bitterly contested issues, is being debated once again. In this compelling book, Diana Coole examines some of the profound political and ethical questions involved. Are ethical objections to government interference with individuals' reproductive freedom definitive? Is it possible to limit population in a non-coercive way that is consistent with liberal-democratic values? Interweaving erudite original analysis with an accessible overview of the crucial debates, Coole argues that a case can be made for reducing our numbers in ways that are compatible with human rights. This book will be essential reading for anyone interested in one of the most important questions facing our planet, from concerned citizens to students of politics, sociology, political economy, gender studies and environmental studies.
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<div> This book aims to initiate among students and other readers critical and interdisciplinary reflections on key problems concerning development, gender relations, peace and environment, with a special emphasis on North-South relations. This volume offers a selection of the author's research in different parts of the world during 50 years of contributing to an interdisciplinary scientific debate and addressing social answers to urgent global problems. After the author's biography and bibliography, the second part analyses the development processes of several countries in the South that resulted in a dynamic of underdevelopment. The deep-rooted gender discrimination is also reflected in the destructive exploitation of natural resources and the pollution of soils, water and air. Since the beginning of the Anthropocene in the mid-20th century, the management of human society and global resources has been unsustainable and has created global environmental change and multiple conflicts over scarce and polluted resources. Peace and development policies aiming at gender equity and sustainable environmental management, where water and food are crucial for the survival of humankind, focus on systemic alternatives embedded in a path of sustainability transition. </div> <div> <br> </div> <div> •  This book reviews multiple influences from Europe, Africa and Latin America on a leading social scientist and activist on gender, development and environment aiming at a world with equity, sustainability, peace and harmony between nature and humans. </div>•  This pioneer volume analyses social and environmental conflicts and peace processes in Latin America, with a special focus on Mexico, by addressing the development of under-development, global environmental change, poverty, nutrition and the North-South gap. <div> • This volume focuses on environmental deterioration with a special emphasis on food and water and proposes systemic changes towards a sustainability transition with peace, regional development and gender equity. </div> <div> • This pioneering work offers alternative approaches to regional development, food sovereignty and holistic development processes from a gender perspective. </div> <div> <br> </div> <div>   <br> </div> <div> <br> </div>
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Support teachers with more effective instructional leadership Leading for Professional Learning offers field-tested guidance to help school leaders more effectively support teachers' professional development. Leadership is crucial to professional learning, providing the necessary systems and structures that enable teachers to improve their own practice and in turn, improve student learning. With an illustrative case study, this book provides invaluable guidance, packed with practical tools, processes, and expert advice. Because each school differs in terms of strengths and needs, this book steers away from prescriptivism and shows you how to construct a support plan tailored to your unique context. Specific teaching and leadership frameworks guide you through the process of examination, discovery, and execution, equipping you with the necessary tools and insight you need to make positive changes for your teachers - and ultimately, your students. A must-read resource for principals, administrators, and other school and district leadership, this book helps you set your school on the path to continuous improvement. * Determine your school's professional learning needs * Leverage existing support structures for the greatest effect * Understand the role of leadership in sponsoring and following up on professional learning * Ensure intentional changes in teacher practice and student learning Empowering teachers to improve their craft goes beyond merely offering opportunity; it requires collaboration with teachers every step of the way, a deep understanding of how best to support professional learning, a clear set of goals for both individual sessions and an overarching mission, and the necessary technical and relational support required to see these opportunities through. Written by experts from the University of Washington Center for Educational Leadership, Leading for Professional Learning provides real-world advice that has been proven effective in school districts across the nation.
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<div> This book explores poetry and pedagogy in practice across the lifespan. Poetry is directly linked to improved literacy, creativity, personal development, emotional intelligence, complex analytical thinking and social interaction: all skills that are crucial in contemporary educational systems. However, a narrow focus on STEM subjects at the expense of the humanities has led educators to deprioritize poetry and to overlook its interdisciplinary, multi-modal potential. The editors and contributors argue that poetry is not a luxury, but a way to stimulate linguistic experiences that are formally rich and cognitively challenging. To learn through poetry is not just to access information differently, but also to forge new and different connections that can serve as reflective tools for lifelong learning. This interdisciplinary book will be of value to teachers and students of poetry, as well as scholars interested in literacy across the disciplines. <br> </div>
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<div> Provide evidence-based answers that can be measured and relied upon by your business. Database administrators will be able to make sound architectural decisions in a fast-changing landscape of virtualized servers and container-based solutions based on the empirical method presented in this book for answering “what if” questions about database performance. </div> <div> <br> </div> <div> Today’s database administrators face numerous questions such as:  </div> <div> <ul> <li>What if we consolidate databases using multitenant features? <br></li> <li>What if we virtualize database servers as Docker containers? <br></li> <li>What if we deploy the latest in NVMe flash disks to speed up IO access?<br></li> <li>Do features such as compression, partitioning, and in-memory OLTP earn back their price? <br></li> <li>What if we move our databases to the cloud?<br></li> </ul> </div> <div> As an administrator, do you know the answers or even how to test the assumptions? </div> <div> <br> </div> <div> <i><b>Database Benchmarking and Stress Testing</b></i> introduces you to database benchmarking using industry-standard test suites such as the TCP series of benchmarks, which are the same benchmarks that vendors rely upon. You’ll learn to run these industry-standard benchmarks and collect results to use in answering questions about the performance impact of architectural changes, technology changes, and even down to the brand of database software. You’ll learn to measure performance and predict the specific impact of changes to your environment. You’ll know the limitations of the benchmarks and the crucial difference between benchmarking and workload capture/reply.  <br> </div> <div> <br> </div>This book teaches you how to create empirical evidence in support of business and technology decisions. It’s about not guessing when you should be measuring. Empirical testing is scientific testing that delivers measurable results. Begin with a hypothesis about the impact of a possible architecture or technology change. Then run the appropriate benchmarks to gather data and predict whether the change you’re exploring will be beneficial, and by what order of magnitude. Stop guessing. Start measuring. Let <b><i>Database Benchmarking and Stress Testing</i></b> show the way. <div> <br> </div> <div> <br> </div> <div> <b>What You'll Learn</b> </div> <div> <div> <ul> <li>Understand the industry-standard database benchmarks, and when each is best used<br></li> <li>Prepare for a database benchmarking effort so reliable results can be achieved<br></li> <li>Perform database benchmarking for consolidation, virtualization, and cloud projects<br></li> <li>Recognize and avoid common mistakes in benchmarking database performance</li> <li>Measure and interpret results in a rational, concise manner for reliable comparisons</li> <li>Choose and provide advice o...
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The dominant model of democratic politics emphasizes reason at the expense of the passions. Passions have been treated as dangerous, the opposite of reason and the enemy of virtue. Paul Ginsborg and Sergio Labate challenge this model and put forward a very different view, developing an account of modern democratic politics in which both passions and reason play a crucial role. To do justice to the role of passions in politics, we must pay close attention to the way in which they circulate among us; then we must develop a suitable language to describe them - an 'alphabet of the passions' that enables us to understand how they combine with one another and connect with certain states of mind in order to shape political outcomes. Adopting this approach enables the authors to shed new light on one of the major phenomena of our time - the triumph of neoliberalism on a world scale. Neoliberalism has worked so well because it has incorporated its own romantic and individualist version of the passions into its worldview, seducing both individuals and families with the allure of consumption. By developing a new model of democratic politics based on the interplay of passions and reason, Ginsborg and Labate provide a much needed framework for understanding the crucial role that passions play in the unfolding of political life. At a time when populist leaders are on the ascendancy and political processes are shaped as much by anger, resentment and fear as they are by reason and argument, this refocusing of political analysis on the role of the passions could not be more timely.
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