Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant - and most challenging - areas of drugdiscovery. * Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects * Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies * Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes * Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) * Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market
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Cognitive Virtual Bots are taking the technology and user experience world by storm. This book provides clear guidance on how different cognitive platforms can be used to develop Cognitive Virtual Assistants that enable a conversation by using DialogFlow and advanced Natural Language Processing. <div>   </div> <div> You will start by understanding the technology landscape and various use cases that Cognitive Virtual Assistants can be used in. Early chapters will take you through the basics of Cognitive Virtual Assistants, before moving onto advanced concepts and hands on examples of using IBM Watson Assistant and its advanced configurations with Watson Discovery Services, Watson Knowledge Studio and Spellchecker Service.  </div> <div> <br> </div> <div> You'll then examine integrations that enrich the Cognitive Virtual Assistant by providing data around weather, locations, stock markets. The book concludes by providing a glimpse of what to expect in the future for Cognitive Virtual Assistants. </div> <div> <br> </div> <div> <b>What You'll Learn</b> <br> </div> <div> <div> <ul> <li> <div> Review the fundamentals of Cognitive Virtual Assistants. </div></li> <li> <div> Develop a Cognitive Virtual Assistant from scratch using IBM Watson platform. </div></li> <li> <div> Integrate and enrich your Virtual Agent with other services such as weather, location and stocks. </div></li> <li> <div> Instantly deliver your bot on major messaging channels such as Skype, SMS, and Webchat </div></li> <li> <div> Train your Cognitive Virtual Agent on specific use cases. </div></li> </ul> <div> <b>Who This Book Is For</b> </div> <div> AI and machine learning engineers, cognitive solutions architects and developers would find the book extremely useful </div> </div> </div> <div> <br> </div>
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This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites. Amongst others, this group of endoparasites includes the causative agents of Malaria, Toxoplasmosis, and Babesiosis, the latter occurring mainly in animals. Written by renowned scientific experts from academia and industry, the book focuses on currentdrug development approaches for all apicomplexan diseases making it appealing to a large audience, ranging from research labs in academia to the human and veterinarian pharmaceutical industry. This work is the second volume of the new book series 'Drug Discovery in Infectious Diseases', edited by Prof. Dr Paul M. Selzer.
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In this captivating novel The Dance of Eternity, Ayoka finds herself at a crossroads in life where she must embark on a profound inner journey. As she unravels the complexities of her emotions and confronts her long-buried fears, Ayoka is forced to grapple with the truth that she had once closed her eyes to. This transformative journey takes readers on a soul-stirring adventure, where they are invited to open their hearts and eyes to the depths of human experience. With its raw and honest portrayal of self-discovery, The Dance of Eternity offers a mesmerizing exploration of love, loss, courage and the unyielding power of the human spirit. Prepare to be moved and swept away by this poignant book that reconnects you to your soul.
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<p>In their approach to Earth dynamics the authors consider the fundamentals of <i>Jacobi Dynamics</i> (1987, Reidel) for two reasons. First, because satellite observations have proved that the Earth does not stay in hydrostatic equilibrium, which is the physical basis of today’s treatment of geodynamics. And secondly, because satellite data have revealed a relationship between gravitational moments and the potential of the Earth’s outer force field (potential energy), which is the basis of <i>Jacobi Dynamics</i>. This has also enabled the authors to come back to the derivation of the classical virial theorem and, after introducing the volumetric forces and moments, to obtain a generalized virial theorem in the form of Jacobi’s equation. Thus a physical explanation and rigorous solution was found for the famous Jacobi’s equation, where the measure of the matter interaction is the energy. <br>The main dynamical effects which become understandable by that solution can be summarized as follows: <br><i>• </i>the kinetic energy of oscillation of the interacting particles which explains the physical meaning and nature of the gravitation forces; <br><i>• </i>separation of the shell’s rotation of a self-gravitating body with respect to the mass density; <br>difference in angular velocities of the shell rotation; <br><i>• </i>continuity in changing the potential of the outer gravitational force field together with changes in density distribution of the interacting masses (volumetric center of masses); <br><i>• </i>the nature of the precession of the Earth, the Moon and satellites; the nature of the rotating body’s magnetic field and the generation of the planet’s electromagnetic field.<br>As a final result, the creation of the bodies in the Solar System having different orbits was discussed. This result is based on the discovery that all the averaged orbital velocities of the bodies in the Solar System and the Sun itself are equal to the first cosmic velocities of their proto-parents during the evolution of their redistributed mass density. <br><br><b>Audience<br></b>The work is a logical continuation of the book <i>Jacobi Dynamics</i> and is intended for researchers, teachers and students engaged in theoretical and experimental research in various branches of astronomy (astrophysics, celestial mechanics and stellar dynamics and radiophysics), geophysics (physics and dynamics of the Earth’s body, atmosphere and oceans), planetology and cosmogony, and for students of celestial, statistical, quantum and relativistic mechanics and hydrodynamics.</p>
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The Last Days of Richard III contains a new and uniquely detailed exploration of Richard's last 150 days. By deliberately avoiding the hindsight knowledge that he will lose the Battle of Bosworth Field, we discover a new Richard: no passive victim, awaiting defeat and death, but a king actively pursuing his own agenda. It also re-examines the aftermath of Bosworth: the treatment of Richard's body; his burial; and the construction of his tomb. And there is the fascinating story of why, and how, Richard III's family tree was traced until a relative was found, alive and well, in Canada. Now, with the discovery of Richard's skeleton at the Greyfrairs Priory in Leicester, England, John Ashdown-Hill explains how his book inspired the dig and completes Richard III's fascinating story, giving details of how Richard died, and how the DNA link to a living relative of the king allowed the royal body to be identified.
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"A chance meeting, a fleeting love, and an unforgettable night." Immerse yourself in White Nights, Fyodor Dostoevsky's beautifully written tale of longing, love, and self-discovery. Set against the glowing backdrop of St. Petersburg's magical white nights, this novella follows a lonely dreamer whose life is changed when he encounters a mysterious woman during one of his midnight walks. Over the course of four nights, their conversations lead to unexpected intimacy, hope, and bittersweet realizations. Dostoevsky's poignant exploration of human connection and desire touches the deepest corners of the heart. With its lyrical prose and emotional depth, White Nights remains one of his most beloved works, resonating with anyone who has ever felt the joy—and sorrow—of unspoken love. Praise for White Nights: "A captivating novella, rich in emotion and poetic beauty." – Literary Critic's Journal "Dostoevsky's timeless tale of fleeting love is a masterpiece in its own right." – Classic Literature Review Experience the romance and melancholy of White Nights for yourself. This story of love found and lost is sure to stay with you long after the final page. Get your copy of White Nights today and journey into the heart of Dostoevsky's most romantic tale.
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This booklet is about what can be read on the labels attached to the insects in a historical collection. These labels are labeled with the name of the animal, location, date of discovery and collector's name. At least that's how it's been said to have been since around 1905. This insect collection on which this is based covers the period from 1868 to 1963 and therefore also contains contemporary wit-nesses to historical events (e.g. Versaille 1919, Kherson 1942) that are no longer familiar to young people. Also included are insects from collectors with interesting résumés that are not even known to insiders, as well as expeditions and real adventure trips (Hedin, Citroen). Socially relevant aspects are also highlighted. The whole thing is peppered with numerous quotes from old reports from collectors, legends and myths as well as aspects of art and religion. The individual chapters are written in a relaxed, easy-to-understand "conversational tone" and are intentionally kept short at 1 – 2 pages so as not to become boring. It's about overviews, not about in-depth information. However, it is not an encyclopedia, not a travel guide, not a textbook or explanatory book . It is a reading book and is intended to convey so much joy that the reader can delve deeper into general education topics on their own. There is a lack of this, especially among biology students: the so-called clas-sic general education has largely been lost there. There were 2 impetus for this booklet: the object " Hister hotten-tota " (chapter "It all began..") as well as the ignorance of the stu-dents around me when I was working on the collection about many different historical and geographical events and contexts.
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